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慢性腎臓病(CKD)の発症メカニズム

腎臓の検査をせずに放置すると、腎機能は低下し続けます2,14。 メカニズムは下記の通りです。

CKD Kidney Overlay

糸球体内圧の上昇

患者さんに慢性腎臓病(CKD)の初期症状がなくても、腎臓内では糸球体内圧が上昇しています2,14。

糸球体内圧が上昇すると、ネフロンがゆっくりと破壊され、腎機能低下が生じます2,3,14。

腎臓病糸球体内圧
腎臓病糸球体内圧

INSIDE THE KIDNEYS,
PRESSURE IS BUILDING

Inside kidneyInside kidneyLOOK INSIDE

腎臓内の圧力が上昇します

CKD Kidney Overlay

糸球体内圧の上昇

患者さんに慢性腎臓病(CKD)の初期症状がなくても、腎臓内では糸球体内圧が上昇しています2,14。

糸球体内圧が上昇すると、ネフロンがゆっくりと破壊され、腎機能低下が生じます2,3,14。

CKD＝慢性腎臓病；CV＝心血管；eGFR＝推算糸球体濾過量；GFR＝糸球体濾過量

References

  1. Ryan TP et al. Am J Med. 2007;120(11):981–986.
  2. Ravera M et al. Am J Kidney Dis. 2011;57(1):71–77.
  3. GBD Chronic Kidney Disease Collaboration. Lancet. 2020;395(10225):709–733.
  4. Alabama Department of Public Health. Special Task Force on Chronic Kidney Disease report. April 2007. Accessed 7 April 2021.
    https://www.alabamapublichealth.gov/index.html
  5. Kidney Disease: The Basics. National Kidney Foundation. Published May 2020. Accessed 7 April 2021.
    https://www.kidney.org/sites/default/files/web_kidneybasics_v4.pdf
  6. Brenner BM et al. N Engl J Med. 2001;345(12):861–869.
  7. Go AS et al. N Engl J Med. 2004;351(13):1296–1305.
  8. Estimated glomerular filtration rate (eGFR). National Kidney Foundation. Reviewed 14 September 2020. Accessed 7 April 2021.
    https://www.kidney.org/atoz/content/gfr
  9. Ghaderian SB et al. J Renal Inj Prev. 2014;3(4):109–110.
  10. Courser WG et al. Kidney Int. 2011;80(12):1258–1270.
  11. Chronic kidney disease basics. Centers for Disease Control and Prevention. Page reviewed 7 February 2020. Accessed 7 April 2021.
    https://www.cdc.gov/kidney-disease/about/?CDC_AAref_Val=https://www.cdc.gov/kidneydisease/basics.html
  12. Kidney Disease Stats. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. Reviewed December 2016. Accessed 7 April 2021.
    https://www.niddk.nih.gov/health-information/health-statistics/kidney-disease
  13. Yacoub R et al. BMC Public Health. 2010;10:731.
  14. Schnaper HW. Pediatr Nephrol. 2014;29(2):193–202.
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